Q: Indomethacin makes nephrogenic Diabetes Insipidus (choose one)

A) Worse

B) Better

C) No response

- choose one

Answer: B

Indomethacin has shown to help in nephrogenic diabetes insipidus particulary in drug induced diabetes insipidus like lithium. Most of the literature and case reports in this regard are 20-25 years old but recently there is a renewed interest in this phenomenon.

1. Indomethacin in streptozocin-induced nephrogenic diabetes insipidus - American Journal of Kidney Diseases Volume 9, Issue 1 , Pages 79-83, January 1987

2. Indomethacin in the treatment of lithium-induced nephrogenic diabetes insipidus, Arch Intern Med. 1989 May;149(5):1123-6.

3. Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus - clinicaltrials.gov